Azadideoxyadenosine: Synthesis, enzymology, and anti-HIV activity

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

Synthesis of an azanucleoside, a new analogue of dideoxyadenosine, is described. This compound is only slowly deaminated by mammalian adenosine deaminase and it is a substrate for adenosine kinase. It exhibits in vitro anti-HIV activity.

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