Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.

Knowledge Graph

Similar Paper

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains
Bioorganic & Medicinal Chemistry Letters 2006.0
Design, Synthesis, and Structure–Activity Relationship Studies of 4-Quinolinyl- and 9-Acrydinylhydrazones as Potent Antimalarial Agents
Journal of Medicinal Chemistry 2008.0
Design, synthesis and antimalarial activity of a glyoxylylhydrazone library
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents
Bioorganic & Medicinal Chemistry Letters 2008.0
Synthesis and evaluation of the antiplasmodial activity of novel indeno[2,1-c]quinoline derivatives
Bioorganic & Medicinal Chemistry 2014.0
Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds
Bioorganic & Medicinal Chemistry 2011.0
Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum
Bioorganic & Medicinal Chemistry Letters 2012.0
Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents
Medicinal Chemistry Research 2012.0
New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo
Bioorganic & Medicinal Chemistry Letters 2015.0
N -Piperonyl substitution on aminoquinoline-pyrimidine hybrids: Effect on the antiplasmodial potency
European Journal of Medicinal Chemistry 2017.0