Posaconazole Enhances the Activity of Amphotericin B against Aspergillus Hyphae In Vitro

Antimicrobial Agents and Chemotherapy
2007.0

Abstract

The MICs and fractional inhibitory concentrations of posaconazole (POS) and voriconazole (VRZ), alone and in combination with amphotericin B (AMB), for the conidia and hyphae of 100 Aspergillus isolates were evaluated. POS-AMB had more synergistic activity against hyphae (75% of isolates) than VRZ-AMB (37%) and significantly more synergistic activity against hyphae than against conidia (12%).

DOI： 10.1128/aac.01024-06

Knowledge Graph

Similar Paper

Posaconazole Enhances the Activity of Amphotericin B against Aspergillus Hyphae In Vitro
Antimicrobial Agents and Chemotherapy 2007.0
Posaconazole Enhances the Activity of Amphotericin B against Hyphae of Zygomycetes In Vitro
Antimicrobial Agents and Chemotherapy 2008.0
Interactions between Triazoles and Amphotericin B in Treatment of Disseminated Murine Infection by Fusarium oxysporum
Antimicrobial Agents and Chemotherapy 2009.0
In Vitro Activities of Amphotericin B, Caspofungin, Itraconazole, Posaconazole, and Voriconazole against 45 Clinical Isolates of Zygomycetes: Comparison of CLSI M38-A, Sensititre YeastOne, and the Etest
Antimicrobial Agents and Chemotherapy 2007.0
In Vitro Susceptibilities of 217 Clinical Isolates of Zygomycetes to Conventional and New Antifungal Agents
Antimicrobial Agents and Chemotherapy 2007.0
Correlation of In Vitro Activity, Serum Levels, and In Vivo Efficacy of Posaconazole against Rhizopus microsporus in a Murine Disseminated Infection
Antimicrobial Agents and Chemotherapy 2009.0
Posaconazole Prophylaxis in Experimental Systemic Zygomycosis
Antimicrobial Agents and Chemotherapy 2007.0
Posaconazole Activity against Candida glabrata after Exposure to Caspofungin or Amphotericin B
Antimicrobial Agents and Chemotherapy 2008.0
In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes
Antimicrobial Agents and Chemotherapy 2009.0
Activity of Posaconazole and Other Antifungal Agents against Mucorales Strains Identified by Sequencing of Internal Transcribed Spacers
Antimicrobial Agents and Chemotherapy 2009.0