A Novel Class of Inhibitors of Peptide Deformylase Discovered through High-Throughput Screening and Virtual Ligand Screening

A Novel Class of Inhibitors of Peptide Deformylase Discovered through High-Throughput Screening and Virtual Ligand Screening Identification of novel potent bicyclic peptide deformylase inhibitors Discovery and Refinement of a New Structural Class of Potent Peptide Deformylase Inhibitors Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition New peptide deformylase inhibitors design, synthesis and pharmacokinetic assessment Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections Bacterial Peptide deformylase inhibition of cyano substituted biaryl analogs: Synthesis, in vitro biological evaluation, molecular docking study and in silico ADME prediction Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase