Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching

Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching Which aminoglycoside ring is most important for binding? a hydropathic analysis of gentamicin, paromomycin, and analogues Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics:  C2‘ ‘ Ether Analogues of Paromomycin Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity Binding of Aminoglycosidic Antibiotics to the Oligonucleotide A-Site Model and 30S Ribosomal Subunit:  Poisson−Boltzmann Model, Thermal Denaturation, and Fluorescence Studies Enhanced binding of aminoglycoside dimers to a “dimerized” A-site 16S rRNA construct Aminoglycoside activity observed on single pre-translocation ribosome complexes Synthesis, antiribosomal and antibacterial activity of 4′-O-glycopyranosyl paromomycin aminoglycoside antibiotics Study of aminoglycoside–nucleic acid interactions by an HPLC method Use of a fluorescence assay to determine relative affinities of semisynthetic aminoglycosides to small RNAs representing bacterial and mitochondrial A sites