2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: Synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols

Bioorganic & Medicinal Chemistry
2007.0

Abstract

The allylation of appropriate benzoin in presence of indium metal followed by m-CPBA mediated cyclization gave 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols. Investigations on 59 human tumor cell lines of these compounds identify four compounds exhibiting significant growth inhibition of tumor cells at particular cell lines. Compound 12 is very specific toward CCRF-CEM and SR cell lines of leukemia.

Knowledge Graph

Similar Paper

2,3,5-Substituted tetrahydrofurans as cancer chemopreventives. Part 1: Synthesis and anti-cancer activities of 5-hydroxymethyl-2,3-diaryl-tetrahydro-furan-3-ols
Bioorganic & Medicinal Chemistry 2007.0
2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols
European Journal of Medicinal Chemistry 2008.0
Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity
European Journal of Medicinal Chemistry 2012.0
Synthesis and antitumor evaluation of 2,3-diarylbenzofuran derivatives on HeLa cells
Bioorganic & Medicinal Chemistry Letters 2017.0
The short way to chiral compounds with hexahydrofluoreno[9,1-bc]furan framework: Synthesis and cytotoxic activity
Bioorganic & Medicinal Chemistry 2015.0
Synthesis and anti-tumor activity of novel ethyl 3-aryl-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and biological evaluation of tetrazole containing compounds as possible anticancer agents
MedChemComm 2011.0
Mechanism Inspired Development of Rationally Designed Dihydrofolate Reductase Inhibitors as Anticancer Agents
Journal of Medicinal Chemistry 2012.0
Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents
Bioorganic & Medicinal Chemistry Letters 2007.0
Solid-phase synthesis of 2′-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines
Bioorganic & Medicinal Chemistry 2012.0