Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides

European Journal of Medicinal Chemistry
2007.0

Abstract

A series of novel fluorocyclopropyl nucleosides were synthesized starting from acetol using the Simmons-Smith reaction as a key reaction. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the uracil analogue 22 showed moderate anti-HCMV activity (10.61 microg/mL, in AD-169).

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