Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

The design and synthesis of new fluoroquinolone antibacterial agents having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against gram-positive organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin.

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