Chemotherapy of leishmaniasis. Part V: Synthesis and in vitro bioevaluation of novel pyridinone derivatives

European Journal of Medicinal Chemistry
2007.0

Abstract

Some novel 2-substituted pyridinone derivatives exemplified by 3 and 4 have been synthesized from 2-methyl-gamma-pyrone and screened towards in vitro antileishmanial activity profile. Some of the compounds such as 3a, 3b, 4i and 4j displayed good antileishmanial profile.

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