Discovery of 1,4-Didydroxy-2-naphthoate Prenyltransferase Inhibitors:  New Drug Leads for Multidrug-Resistant Gram-Positive Pathogens

Discovery of 1,4-Didydroxy-2-naphthoate Prenyltransferase Inhibitors:  New Drug Leads for Multidrug-Resistant Gram-Positive Pathogens Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis Synthesis, optimization, in vitro and in vivo study of bicyclic substituted amine as MenA inhibitor Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive Staphylococcus aureus Biosynthesis of bacterial menaquinones. Menaquinone mutants of Escherichia coli Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum