Praziquantel derivatives I: Modification of the aromatic ring

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis.

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