Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells

Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38αMAPK inhibitors in Werner syndrome cells The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor Pyridinylquinoxalines and Pyridinylpyridopyrazines as Lead Compounds for Novel p38α Mitogen-Activated Protein Kinase Inhibitors 6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354):  A Potent and Selective p38 Kinase Inhibitor Synthesis and biological evaluation of p38α kinase-targeting dialkynylimidazoles Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis