Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 microg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis.

Knowledge Graph

Similar Paper

Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents
Bioorganic & Medicinal Chemistry Letters 2007.0
Thiophene containing triarylmethanes as antitubercular agents
Bioorganic & Medicinal Chemistry Letters 2008.0
Novel imidazo[2,1-b][1,3,4]thiadiazole carrying rhodanine-3-acetic acid as potential antitubercular agents
Bioorganic & Medicinal Chemistry Letters 2012.0
Synthesis and antibacterial activity of 2,2'-dithiobis(benzamide) derivatives against Mycobacterium species
Journal of Medicinal Chemistry 1985.0
New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl)thiazol-4(%H)-one as potent antitubercular agents
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis, spectral studies and biological evaluation of a novel series of 2-substituted-5,6-diarylsubstituted imidazo(2,1-b)-1,3,4-thiadiazole derivatives as possible anti-tubercular agents
Medicinal Chemistry Research 2012.0
Synthesis and antimycobacterial activity of some alkyl [5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates
Bioorganic & Medicinal Chemistry Letters 2006.0
Synthesis and evaluation of a novel series of pseudo-cinnamic derivatives as antituberculosis agents
Bioorganic & Medicinal Chemistry Letters 2009.0
Design, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents
MedChemComm 2018.0
Synthesis and antimycobacterial activity of some phthalimide derivatives
Bioorganic & Medicinal Chemistry 2012.0