Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route

Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route N-Substituted-2-alkyl- and 2-arylnorapomorphines: Novel, highly active D2 agonists Synthesis and SAR study of a novel series of dopamine receptor agonists Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D₂/D₃Receptor Agonist Selectivity Structure–Activity Relationship Study ofN⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Development of Highly Selective D3 Dopamine Receptor Agonists along with a Highly Potent D2/D3 Agonist and Their Pharmacological Characterization Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand Further Structure–Activity Relationships Study of Hybrid 7-{[2-(4-Phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol Analogues: Identification of a High-Affinity D3-Preferring Agonist with Potent in Vivo Activity with Long Duration of Action Bioisosteric Heterocyclic Versions of 7-{[2-(4-Phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: Identification of Highly Potent and Selective Agonists for Dopamine D3 Receptor with Potent in Vivo Activity Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception Synthesis and Pharmacological Evaluation of Potent and Highly Selective D₃ Receptor Ligands:  Inhibition of Cocaine-Seeking Behavior and the Role of Dopamine D₃/D₂ Receptors