Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

A new natural product, lysianadioic acid, was isolated from the plant Lysiana subfalcata as a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC(50) of 0.36 microM. This is the first known example of a small molecule CPB inhibitor isolated from plant origin. Its structure was determined by NMR spectroscopy.

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