Thiosemicarbazones active against Clostridium difficile

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.

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