A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

Tumor targeting peptides are promising vehicles for site-directed cancer therapy. Pep42, a cyclic 13-mer oligopeptide that specifically binds to glucose-regulated protein 78 (GRP78) and internalized into cancer cells, represents an excellent vehicle for tumor cell-specific chemotherapy. Here, we report the synthesis and evaluation of Pep42-prodrug conjugates that contain a cathepsin B-cleavable linker, resulting in the traceless release of drug inside the cancer cells.

Knowledge Graph

Similar Paper

A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy
Bioorganic & Medicinal Chemistry Letters 2008.0
Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin
Bioorganic & Medicinal Chemistry Letters 2006.0
Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment
European Journal of Medicinal Chemistry 2021.0
Synthesis and Biological Evaluation of Dimeric RGD Peptide−Paclitaxel Conjugate as a Model for Integrin-Targeted Drug Delivery
Journal of Medicinal Chemistry 2005.0
Proteolytically Stable Cancer Targeting Peptides with High Affinity for Breast Cancer Cells
Journal of Medicinal Chemistry 2011.0
Paclitaxel Derivatives for Targeted Therapy of Cancer:  Toward the Development of Smart Taxanes
Journal of Medicinal Chemistry 1999.0
Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations
Journal of Medicinal Chemistry 2020.0
Synthesis, biological studies and molecular dynamics of new anticancer RGD-based peptide conjugates for targeted drug delivery
Bioorganic & Medicinal Chemistry 2016.0
Gemcitabine anti-proliferative activity significantly enhanced upon conjugation with cell-penetrating peptides
Bioorganic & Medicinal Chemistry Letters 2017.0
Development of a peptide-based bifunctional chelator conjugated to a cytotoxic drug for the treatment of melanotic melanoma
MedChemComm 2018.0