Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70 Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function:  Rational Identification of a New Anticancer Lead Efrapeptin J, a New Down-regulator of the Molecular Chaperone GRP78 from a Marine Tolypocladium sp. Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone