Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration

Bioorganic & Medicinal Chemistry
2008.0

Abstract

The intermediate 3 is converted by the nucleophilic attack of the appropriate aryl (heterocyclic) amine under microwave irradiation into the chiral (E) isomers of title compound 4. These compounds exhibited weak to good anti-TMV bioactivity with (R)-4p showing significant enhancement of disease resistance in tobacco leaves.

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