Synthesis and Cytotoxic Evaluation of Some Cribrostatin–Ecteinascidin Analogues

Journal of Natural Products
2008.0

Abstract

Analogues of cribrostatin IV ( 1) and the potent antineoplastic agent ecteinascidin 743 ( 2) have been synthesized. The cytotoxic activity of these compounds ( 5, 14, 20) has been determined, and the cyanoamine-cribrostatin analogue ( 14) exhibits a 20-fold improvement with regard to the natural product 1.

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