Isoxazolone Based Inhibitors of p38 MAP Kinases

Isoxazolone Based Inhibitors of p38 MAP Kinases Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase Design, Synthesis, and Biological Evaluation of Novel Tri- and Tetrasubstituted Imidazoles as Highly Potent and Specific ATP-Mimetic Inhibitors of p38 MAP Kinase: Focus on Optimized Interactions with the Enzyme’s Surface-Exposed Front Region 3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38α Mitogen Activated Protein Kinase and Casein Kinase 1δ Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase Unexpected Reaction of 2-Alkylsulfanylimidazoles to Imidazol-2-ones: Pyridinylimidazol-2-ones as Novel Potent p38α Mitogen-Activated Protein Kinase Inhibitors Syntheses and structure–activity relationships for some triazolyl p38α MAPK inhibitors Benzimidazolone p38 inhibitors Novel Substituted Pyridinyl Imidazoles as Potent Anticytokine Agents with Low Activity against Hepatic Cytochrome P450 Enzymes Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase