Cationic Reduction of Bastadin-4 to Bastadin-5. Preparation of 5-[2H]-Bastadin-5 by Site-Specific Isotopic Labeling

Journal of Natural Products
2003.0

Abstract

A chemoselective conversion of bastadin-4 to the important Ca2+ channel modulator bastadin-5 (1a) has been achieved using cationic hydrogenation (Et3SiH, TFA, 60%). Specifically deuterated bastadin-5 (1b, >95 at. %) was prepared following this method and the simplified 1H NMR H-5/H2-6 spin system of 1b exploited to study temperature-dependent macrocyclic ring dynamics.

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