Isolation and Characterization of Palystatins A-D

Journal of Natural Products
1982.0

Abstract

Four new and relatively low molecular weight (approximately 3,000-5,000), cell growth (PS) inhibitory peptides designated palystatins A-D have been isolated from the Indian Ocean Palythao liscia Haddon and Duerden. The Isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100) guided by bioassay with the P388 murine lymphocytic leukemia (PS system). Palystatins A-D exhibited PS cytotoxicity in the range ED50 0.02-0.0023 microgram/ml.

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