Chemistry of Acronycine I. Carbon- 13 NMR Studies of Acronycine and Related Compounds

Journal of Natural Products
1983.0

Abstract

Complete and unambiguous 13C-nmr assignments have been made for acronycine (1) through examination of both fully coupled and INEPT spectra. By analogy, chemical shift assignments were also made for dihydroacronycine (2), noracronycine (3), and dihydronoracronycine (4). A characteristic deshielding effect on an N-methyl group in this system was disclosed. Cytotoxicity testing using the KB system demonstrated that the O-methyl group is essential for activity.

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