Achyrofuran, a New Antihyperglycemic Dibenzofuran from the South American Medicinal Plant Achyrocline satureioides

Journal of Natural Products
2002.0

Abstract

A new prenylated dibenzofuran, achyrofuran (2), was isolated from an extract of Achyrocline satureioides by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Compound 2significantly lowered blood glucose levels in this model when administered orally at 20 mg/kg q.d.

Knowledge Graph

Similar Paper

Achyrofuran, a New Antihyperglycemic Dibenzofuran from the South American Medicinal Plant Achyrocline satureioides
Journal of Natural Products 2002.0
Maprouneacin, a New Daphnane Diterpenoid with Potent Antihyperglycemic Activity from <i>Maprounea</i> <i>africana</i>
Journal of Natural Products 1999.0
Structure and Antimicrobial Activity of Phloroglucinol Derivatives from <i>Achyrocline satureioides</i>
Journal of Natural Products 2015.0
Designing inhibitors against fructose 1,6-bisphosphatase: Exploring natural products for novel inhibitor scaffolds
European Journal of Medicinal Chemistry 2010.0
Cyclobutane Dimers from the Colombian Medicinal Plant<i>Achyrocline</i><i>b</i><i>ogotensis</i>
Journal of Natural Products 2005.0
New furanoflavanoids, intestinal α-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.)
Bioorganic &amp; Medicinal Chemistry 2009.0
Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii
Bioorganic &amp; Medicinal Chemistry 2012.0
Synthesis of α-amyrin derivatives and their in vivo antihyperglycemic activity☆
European Journal of Medicinal Chemistry 2009.0
Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model
Bioorganic &amp; Medicinal Chemistry Letters 2007.0
Antidiabetic Compounds from <i>Sarracenia purpurea</i> Used Traditionally by the Eeyou Istchee Cree First Nation
Journal of Natural Products 2012.0