Inhibition of Dopamine β-Hydroxylase by Goitrin, a Natural Antithyroid Compound

Journal of Natural Products
1988.0

Abstract

RS-Goitrin can be conveniently prepared by a simplification of the Ettlinger procedure. Goitrin is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase. The administration of goitrin leads to a depression of brain norepinephrine and to an elevation of heart and adrenal dopamine.

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