Efficacy of Fluoroquinolones againstLeptospira interrogansin a Hamster Model

Antimicrobial Agents and Chemotherapy
2007.0

Abstract

Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.

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