The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki–Miyaura cross-coupling reaction

Bioorganic & Medicinal Chemistry
2008.0

Abstract

Novel 3,5-disubstituted ring E analogs of methyllycaconitine were prepared and evaluated in nicotinic acetylcholine receptor binding assays. The desired analogs were prepared through the Suzuki-Miyaura cross-coupling reaction of methyl 5-bromo-nicotinate. The Suzuki-Miyaura cross-coupling reactions of pyridines with electron withdrawing substituents have not been extensively described previously.

Knowledge Graph

Similar Paper

The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki–Miyaura cross-coupling reaction
Bioorganic & Medicinal Chemistry 2008.0
New Tricyclic Aryl Quinazoline Derivatives by Suzuki‐Miyaura Cross‐Coupling
ChemistryOpen 2024.0
Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists
Bioorganic & Medicinal Chemistry Letters 1999.0
Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities
Bioorganic & Medicinal Chemistry 2017.0
Synthesis of arylated coumarins by Suzuki–Miyaura cross-coupling. Reactions and anti-HIV activity
Bioorganic & Medicinal Chemistry 2016.0
Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the α3β4* nicotinic acetylcholine receptors through modifications to the ester
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs
Bioorganic & Medicinal Chemistry 2007.0
Synthesis of potential antitubercular and antimicrobial s-triazine-based scaffolds via Suzuki cross-coupling reaction
Medicinal Chemistry Research 2013.0
Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and Nicotinic Binding Studies on Enantiopure Diazine Analogues of the Novel (2-Chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165
Journal of Medicinal Chemistry 2002.0