The pyrrolizidine alkaloids, echinatine (6), and heliosupine (5) were isolated from Cynoglossum creticum; monocrotaline (10) and crosemperine (11) were isolated from Crotalaria aggriptinary monocrotaline (10) and crossingerine (11) wereisolated from Crotalaria aggriptinary monocrotaline (4), lasicocarpine (2), and europine (3)were isolated from Heliotropium arbainense; show similar activity to that previously reported for indicine N-oxide (12) (2) against P 388 lymphocytic leukemia tumors.