Insulin-releasing activity of a series of phenylalanine derivatives

European Journal of Medicinal Chemistry
2008.0

Abstract

A series of phenylalanine derivatives were synthesized and their biological activities were evaluated. Compounds (S)-3 and (R)-3 exhibited more potent insulin-releasing activity than that of nateglinide, compound (S)-3 also showed insulin-sensitizing activity in vitro. Both compounds were tested for hypoglycemia effect in vivo.

Knowledge Graph

Similar Paper