Synthesis of 3,6-bicyclolides: A novel class of macrolide antibiotics

Bioorganic & Medicinal Chemistry Letters
2008.0

Abstract

The synthesis of 3,6-bicyclolides from erythromycin A oxime is described. This novel class of bridged bicyclic macrolides demonstrates potent in vitro and in vivo activities against a broad spectrum of bacteria including resistant respiratory tract pathogens.

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