Synthesis and anticancer activities of ageladine A and structural analogs

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A series of ageladine A analogs that include 2-aminoimidazo[4,5-c]azepines (seven-membered rings) and 2-amino-3H-imidazo[4,5-c]pyridine (six-membered rings) derivatives were synthesized and evaluated for their anticancer effects against several human cancer cell lines and MMP-2 inhibition in vitro. Only compounds possessing the aromatic azepine (seven-membered ring) core showed anticancer activity with IC(50) values in the low micromolar range.

Knowledge Graph

Similar Paper

Synthesis and anticancer activities of ageladine A and structural analogs
Bioorganic & Medicinal Chemistry Letters 2010.0
A One-Pot Synthesis and Biological Activity of Ageladine A and Analogues
Journal of Medicinal Chemistry 2011.0
Synthesis and evaluation of novel anti-proliferative pyrroloazepinone and indoloazepinone oximes derived from the marine natural product hymenialdisine
European Journal of Medicinal Chemistry 2012.0
Synthesis and cytotoxicity of novel imidazo[4,5- d ]azepine compounds derived from marine natural product ceratamine A
Bioorganic & Medicinal Chemistry Letters 2018.0
Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs
Bioorganic & Medicinal Chemistry Letters 2007.0
Design, Synthesis, and Evaluation of the Antiproliferative Activity of a Series of Novel Fused Xanthenone Aminoderivatives in Human Breast Cancer Cells
Journal of Medicinal Chemistry 2007.0
Design, synthesis and anticancer activity of sulfenylated imidazo-fused heterocycles
Bioorganic & Medicinal Chemistry Letters 2021.0
Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines
European Journal of Medicinal Chemistry 2010.0
Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents
European Journal of Medicinal Chemistry 2011.0
Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe
Bioorganic & Medicinal Chemistry Letters 2016.0