2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats

Medicinal Chemistry Research
2011.0

Abstract

Five distinct organic compounds with protected and unprotected phenolic hydroxyl groups were screened for their a-glucosidase inhibitory potential. Of these compounds, 2,4,6-trihydroxybenzaldehyde (THB) showed the strongest noncompetitive a-glucosidase inhibition (IC50 = 4.60 lM) and the most powerful antioxidant activity (DPPH assay) (IC50 = 71.4 lM) in vitro. In in vivo studies, THB significantly reduced blood glucose levels in normal and diabetic rats after glucose load compared to maltose load.

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