Synthesis and SAR of potent LXR agonists containing an indole pharmacophore

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXRalpha will be disclosed.

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