Small-molecule probe using dual signals to monitor leucine aminopeptidase activity

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

Leucine aminopeptidases (LAPs) are widely distributed in organisms from bacteria to humans, and play crucial roles in cell maintenance and cell growth. Thus, assays for LAP are necessary for measuring its activity and inhibitor potency. In this Letter, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity.

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