Synthesis and biological activities of novel indole derivatives as potent and selective PPARγ modulators

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

Starting from the structure of Telmisartan, a new series of potent and selective PPARgamma modulators was identified. The synthesis, in vitro and in vivo evaluation of the most potent compounds are reported and the X-ray structure of compound 7b bound to the PPARgamma ligand binding domain is described.

DOI： 10.1016/j.bmcl.2009.12.107

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