Synthesis of citrate–ciprofloxacin conjugates

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.

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