Iodine-catalyzed one-pot synthesis and antimalarial activity evaluation of symmetrically and asymmetrically substituted 3,6-diphenyl[1,2,4,5]tetraoxanes

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

A novel iodine-catalyzed one-pot synthesis of symmetrically and asymmetrically substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes is described. The synthetic protocol is general with substituted benzaldehydes and proceeds well under acidic conditions. Total 17 tetraoxanes have been prepared during this study and some of these compounds exhibit promising antimalarial activity. None of the compounds shows any toxicity against vero cells.

Knowledge Graph

Similar Paper

Iodine-catalyzed one-pot synthesis and antimalarial activity evaluation of symmetrically and asymmetrically substituted 3,6-diphenyl[1,2,4,5]tetraoxanes
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes
Bioorganic & Medicinal Chemistry Letters 2008.0
Synthesis, antimalarial activity and cytotoxicity of substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes
Bioorganic & Medicinal Chemistry 2009.0
Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles
Journal of Medicinal Chemistry 2008.0
Synthesis and in vitro antimalarial activity of tetraoxane-amine/amide conjugates
European Journal of Medicinal Chemistry 2011.0
Mixed Steroidal 1,2,4,5-Tetraoxanes:  Antimalarial and Antimycobacterial Activity
Journal of Medicinal Chemistry 2002.0
Chemical Stability of the Peroxide Bond Enables Diversified Synthesis of Potent Tetraoxane Antimalarials
Journal of Medicinal Chemistry 2008.0
Catalysis by molecular iodine: A rapid synthesis of 1,8-dioxo-octahydroxanthenes and their evaluation as potential anticancer agents
Bioorganic & Medicinal Chemistry Letters 2012.0
Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers
Bioorganic & Medicinal Chemistry 2013.0
N-sulfonylpiperidinedispiro-1,2,4,5-tetraoxanes exhibit potent in vitro antiplasmodial activity and in vivo efficacy in mice infected with P. berghei ANKA
European Journal of Medicinal Chemistry 2022.0