Synthesis and hypoglycemic activity evaluation of 7-alkoxyl-rhein

Medicinal Chemistry Research
2012.0

Abstract

A four-step microwave-assisted procedure was used to synthesize 7-alkoxyl-rhein derivatives 5a–e starting from emodin and 1-bromoalkanes. These compounds exhibited hypoglycemic activity by inhibiting a-glucosaccharase, which were influenced by the aliphatic chain length. Results showed that 5c displayed remarkable activity in vitro and in vivo.

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