Integration of Ligand and Structure-Based Virtual Screening for the Identification of the First Dual Targeting Agent for Heat Shock Protein 90 (Hsp90) and Tubulin

Integration of Ligand and Structure-Based Virtual Screening for the Identification of the First Dual Targeting Agent for Heat Shock Protein 90 (Hsp90) and Tubulin Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Structure-based discovery of a new class of Hsp90 inhibitors Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening Virtual screening and biophysical studies lead to HSP90 inhibitors A novel class of Hsp90 inhibitors isolated by structure-based virtual screening Identification of new Hsp90 inhibitors by structure-based virtual screening Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met Discovery and development of heat shock protein 90 inhibitors