Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

In this Letter, we assessed newly synthesized sphingolipid analogs as ligands for peroxisome proliferator-activated receptor (PPAR)alpha, PPARbeta or PPARgamma, using a dual-luciferase reporter system. We tested 640 sphingolipid analogs for ligand activity. As a result, seven types: A9, B9, C9, C50, F66, G66 and H66, were found to show agonistic activities for PPARs.

Knowledge Graph

Similar Paper

Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis of para-Alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of New Chiral Fibrates with PPARα and PPARγ Agonist Activity
Journal of Medicinal Chemistry 2005.0
Design and Synthesis of the First Generation of Dithiolane Thiazolidinedione- and Phenylacetic Acid-Based PPARγ Agonists
Journal of Medicinal Chemistry 2006.0
Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists
Bioorganic & Medicinal Chemistry 2012.0
Synthesis and structure–activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists
Bioorganic & Medicinal Chemistry Letters 2007.0
Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition
Molecules 2021.0
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists
Bioorganic & Medicinal Chemistry 2012.0
New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors α/γ Dual Agonists with Improved Potency and Reduced Adverse Effects on Skeletal Muscle Function
Journal of Medicinal Chemistry 2009.0
Design, synthesis, and structure–activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists
Bioorganic & Medicinal Chemistry Letters 2007.0