Several pyrazolyl-quinazolin-4(3H)-ones 6a– m were synthesized by the cyclization of acrylamides 5a–m with hydrazine hydrate. The overall reaction was carried out by multi step process. The base-catalyzed cyclization of acid chloride 1 with 5-iodo anthranilic acid yielded benzoxazinone 2, which on reaction with hydrazine hydrate afforded amino quinazolin-4(3H)-one 3. The acrylamides 5a–m were easily synthesized by acetylation and then condensation with aromatic aldehyde of quinazolin-4(3H)-one 3. The structural confirmation of the synthesized compounds was carried out on the basis of elemental analyses as well as IR and NMR spectral results. The title compound 6a–m was evaluated for antibacterial and antifungal activity in vitro.