Novel antitubercular diallyl/dibenzylthiosemicarbazones endowed with high activity toward multi-drug-resistant tuberculosis

Medicinal Chemistry Research
2012.0

Abstract

Novel diallyl and dibenzylthiosemicarbazones were prepared by three-step reactions. The compounds were tested for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug-resistant Mycobacterium tuberculosis (MDR-TB). Most of the compounds showed excellent activity toward MDR-TB. Among the thirty compounds (4,5a–o) tested N,N-dibenzyl-2-((5-nitrofuran-2-yl)methylene)hydrazinecarbothioamide (5g) was found to be the most potent compound MICs of 0.55 and 0.12 lM against MTB and MDR-TB.

Knowledge Graph

Similar Paper

Novel antitubercular diallyl/dibenzylthiosemicarbazones endowed with high activity toward multi-drug-resistant tuberculosis
Medicinal Chemistry Research 2012.0
N-Hydroxythiosemicarbazones: Synthesis and in vitro antitubercular activity
Bioorganic & Medicinal Chemistry Letters 2007.0
Discovery of novel antitubercular 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues
Bioorganic & Medicinal Chemistry Letters 2011.0
Antituberculous activity of some aryl semicarbazone derivatives
Bioorganic & Medicinal Chemistry Letters 2004.0
Discovery of New Antitubercular Oxazolyl Thiosemicarbazones
Journal of Medicinal Chemistry 2006.0
Dibenzofuran, dibenzothiophene and N-methyl carbazole tethered 2-aminothiazoles and their cinnamamides as potent inhibitors of Mycobacterium tuberculosis
Bioorganic & Medicinal Chemistry Letters 2018.0
Synthesis and antimycobacterial activities of some new N-acylhydrazone and thiosemicarbazide derivatives of 6-methyl-4,5-dihydropyridazin-3(2H)-one
Medicinal Chemistry Research 2012.0
5-Nitrofuran-2-yl derivatives: Synthesis and inhibitory activities against growing and dormant mycobacterium species
Bioorganic & Medicinal Chemistry Letters 2009.0
Identification of N-Benzyl 3,5-Dinitrobenzamides Derived from PBTZ169 as Antitubercular Agents
ACS Medicinal Chemistry Letters 2018.0
Novel N′-benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents
Bioorganic & Medicinal Chemistry Letters 2012.0