Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity

Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity Design and synthesis of novel isoxazole-based HDAC inhibitors Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity Indole amide hydroxamic acids as potent inhibitors of histone deacetylases Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors The design, synthesis and structure–activity relationships of novel isoindoline-based histone deacetylase inhibitors