Synthesis and antibacterial activity of some novel imidazole-based dicationic quinolinophanes

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

Synthesis of novel quinoline based dicationic benzimidazolophanes and imidazolophanes incorporating various spacer units is described. Some of the quinolinophanes 1b, 3a,3b and 4a exhibit good antibacterial activity against most of the human pathogenic bacteria in the tested concentrations as compared to the other cyclophanes as well as the test control, streptomycin.

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