Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC(50)=0.77 and 0.79microM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

DOI： 10.1016/j.bmcl.2009.05.007

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