2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

The design and synthesis of 2,6-diphenylthiazolo[3,2-b][1,2,4]triazoles characterized by a large aromatic building block bearing cationic side chains are reported. These molecules are evaluated as telomeric G-quadruplex stabilizers and for their selectivity towards duplex DNA by competition experiments. Two compounds (14a, 19) were found active with high selectivity for telomeric G-quadruplex over duplex DNA.

Knowledge Graph

Similar Paper

2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers
Bioorganic & Medicinal Chemistry Letters 2009.0
Aminoacyl−Anthraquinone Conjugates as Telomerase Inhibitors: Synthesis, Biophysical and Biological Evaluation
Journal of Medicinal Chemistry 2008.0
Synthesis and Evaluation of Quindoline Derivatives as G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase
Journal of Medicinal Chemistry 2005.0
Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell Death
Journal of Medicinal Chemistry 2012.0
Antitumor Polycyclic Acridines. 20. Search for DNA Quadruplex Binding Selectivity in a Series of 8,13-Dimethylquino[4,3,2-kl]acridinium Salts: Telomere- Targeted Agents
Journal of Medicinal Chemistry 2008.0
Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response
Journal of Medicinal Chemistry 2018.0
Thiazole orange – Spermine conjugate: A potent human telomerase inhibitor comparable to BRACO-19
European Journal of Medicinal Chemistry 2019.0
Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry
Journal of Medicinal Chemistry 2017.0
G-Quadruplex DNA-binding quaternary alkaloids from Tylophora atrofolliculata
RSC Advances 2016.0
G-Quadruplex DNA-binding quaternary alkaloids from Tylophora atrofolliculata
RSC Advances 2016.0