Bio-inspired synthesis and biological evaluation of a colchicine-related compound library

Bioorganic & Medicinal Chemistry Letters
2012.0

Abstract

A bio-inspired investigation of the reactions of substrates of type 1 with VOF(3) and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2-5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29.

DOI： 10.1016/j.bmcl.2012.04.007

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