Literature

Abstract

Cycling of Streptococcus gordonii (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 microg/ml. The 2-microg/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.

DOI： 10.1128/aac.00939-07

Fitness Cost and Impaired Survival in Penicillin-Resistant Streptococcus gordonii Isolates Selected in the Laboratory

Antimicrobial Agents and Chemotherapy 2008.0

Fitness Costs of Fluoroquinolone Resistance in Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy 2007.0

Fitness of Streptococcus pneumoniae Fluoroquinolone-Resistant Strains with Topoisomerase IV Recombinant Genes

Antimicrobial Agents and Chemotherapy 2008.0

Resistance Selection Studies Comparing the Activity of Razupenem (PTZ601) to Vancomycin and Linezolid against Eight Methicillin-Resistant and Two Methicillin-Susceptible Staphylococcus aureus Strains

Antimicrobial Agents and Chemotherapy 2009.0

A Single Mutation in Enzyme I of the Sugar Phosphotransferase System Confers Penicillin Tolerance to Streptococcus gordonii

Antimicrobial Agents and Chemotherapy 2010.0

Linezolid Resistance in Staphylococcus aureus : Gene Dosage Effect, Stability, Fitness Costs, and Cross-Resistances