Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

An active compound having antitumor activity was isolated from the root of Anthriscus sylvestris. Structural studies revealed that it was deoxypodophyllotoxin (DPPT), and its biological activity was evaluated in HeLa human cervix carcinoma cells. Flow cytometric analysis showed that DPPT arrests the cell cycle in the G2/M phase prior to apoptosis. The mechanisms of action of DPPT involve inhibition of tubulin polymerization, dysregulation of cyclin A and cyclin B1 expression, and activation of caspases-3 and -7.

Knowledge Graph

Similar Paper

Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7
European Journal of Medicinal Chemistry 2012.0
Discovery of Novel N-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment
Journal of Medicinal Chemistry 2022.0
Synthesis of hybrid 4-deoxypodophyllotoxin–5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest
Bioorganic & Medicinal Chemistry Letters 2016.0
Polyalkoxybenzenes from Plants. 5. Parsley Seed Extract in Synthesis of Azapodophyllotoxins Featuring Strong Tubulin Destabilizing Activity in the Sea Urchin Embryo and Cell Culture Assays
Journal of Medicinal Chemistry 2011.0
Investigation of podophyllotoxin esters as potential anticancer agents: Synthesis, biological studies and tubulin inhibition properties
European Journal of Medicinal Chemistry 2015.0
Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors
Bioorganic & Medicinal Chemistry 2014.0
One-pot synthesis and biological evaluation of N -(aminosulfonyl)-4-podophyllotoxin carbamates as potential anticancer agents
Bioorganic & Medicinal Chemistry Letters 2017.0
Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents
European Journal of Medicinal Chemistry 2012.0
4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents
Bioorganic & Medicinal Chemistry 2013.0